Henrie was born in Mission Viejo, California, the son of Linda (née Finocchiaro), a talent manager, and James Wilson Henrie, a producer formerly in real estate. He is the older brother of actor Lorenzo James Henrie. Henrie is of English, German, Swiss-German and Welsh descent on his father's side, and his maternal grandparents were Italian. Henrie was raised as a Roman Catholic, and, in a video chat, stated that he is "a Christian and always will be". He grew up in Phoenix, Arizona. On April 6, 2012, Good Friday, Henrie accompanied Eduardo Verástegui in a speech addressing life issues at the Church of the Most Blessed Sacrament in the city of Piura, Peru.