Her first lead role was as Maddie in the 2005 short film Redemption Maddie. Scagliotti is best known for her portrayal of the character Claudia Donovan in the 2009 series, Warehouse 13 on Syfy. Her character was introduced early in the premiere season and she appeared in most of the remaining episodes (though credited as a guest star until season two). Her character crossed over to Eureka when she guest-starred in the season four episode "Crossing Over". She helped co-host SyFy's Ghost Hunters Live on Halloween 2010. She appeared as Jayna, the female Wonder Twin, in Idol the 8th episode of the ninth season of Smallville.