Deutch began her career with starring roles in the gothic fantasy film Beautiful Creatures (2013) and the horror comedy film Vampire Academy (2014). In 2016, she starred as Beverly in the comedy Everybody Wants Some!! and Stephanie Fleming in the comedy Why Him?. In 2017, she starred as Samantha Kingston in the drama Before I Fall, Erica Vandross in the comedy-drama Flower, and Harper in the romantic comedy Set It Up. She also produced and starred in the films The Year of Spectacular Men (2017) and Buffaloed (2019).