Holland was born in Los Angeles, to cinematographer Keith Holland and actress Darnell Gregorio-De Palma. Her mother was remarried to director Brian De Palma from 1995–97. She grew up with two sisters: Brianna Holland (b. 1988) and Piper De Palma (b. 1996). Holland attended Palisades Charter High School for only six weeks because her career was taking off and school peers were dismissive of her acting pursuits.