In 2009, Pasqualino made his acting debut as the protagonist in the low-budget film Stingers Rule! about a local football team going against property developers who plan to destroy their beloved football ground. Pasqualino has guest starred on Casualty and Miranda. He performed numerous plays and did some modelling.  In 2008, Pasqualino became one of the new series regulars in the third season of the E4 teenage drama television series Skins, which replaces its primary cast members every two seasons. Pasqualino portrayed Freddie McClair, a laid-back weed-smoking college pupil. As season four neared its conclusion, he and the rest of the cast were replaced, as usual. Pasqualino originally auditioned for the part of Tony Stonem in Series 1 of Skins but actor Nicholas Hoult won the part.