Regina started anchoring when she was nine for Splash, a kids' channel and then moved on to work in commercials. Aged 16, she shot for her first film, Kanda Naal Mudhal directed by V. Priya, which also starred Prasanna, Laila and Karthik Kumar. In the film, Regina portrayed Latha, the 21-year-old pregnant sister of Laila's character, and has since mentioned that people still find it hard to believe it was her in that role, as she was very young and wore no make-up. She then appeared alongside fellow newcomer Yogi in Azhagiya Asura, which won good reviews. However the film's low-key release meant that the film failed to gain attention, so she took time out from films and then went on to graduate in psychology from Women's Christian College, Chennai and took another year off before taking a final call on joining movies. During her break she also acted in several short films, most notably Balaji Mohan's Kadhalil Sodhappuvadhu Yeppadi alongside Adith Arun, which was later made into a feature film in 2012 under the same name.