Perlman is known as a collaborator of Hellboy director Guillermo del Toro, having roles in the del Toro films Cronos (1993), Blade II (2002), and Pacific Rim (2013). He is also known for his voice-over work as the narrator of the post-apocalyptic game series Fallout, Clayface in the DC Animated Universe, Slade on the animated series Teen Titans, The Lich on Adventure Time, and The Stabbington Brothers in Disney's animated film Tangled (2010).